Cynomolgus IL10RA Protein|技术资料|价格

IL10RA蛋白产品信息

别名: IL10RA
表达方式: 
A DNA sequence encoding the cynomolgus IL10RA(Thr9-Asn245) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

IL10RA Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 29
分子量: 
The recombinant cynomolgus IL10RA is a disulfide-linked homodimer. The reduced monomer comprises 458 amino acids and has a calculated molecular mass of 51.8 KDa.The apparent molecular mass of the protein is approximately 62-66 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IL10RA Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL10RA蛋白背景综述

CD219, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also recently been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD219 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD219 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD219 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

参考文献

Josephson K. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57 (12): 1908-11.
Tan J C. et al., 1995, J Biol Chem. 270 (21): 12906-11.
Josephson K. et al., 2001, Immunity. 15 (1): 35-46.

规格：50ug

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