Cynomolgus FGFR4 / FGF Receptor 4 Protein|现货|产品详情

FGFR4 / FGF Receptor 4蛋白产品信息

别名: FGFR4
表达方式: 
A DNA sequence encoding the cynomolgus FGFR4(Met1-Asp369) was expressed with the Fc region of mouse IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

FGFR4 / FGF Receptor 4 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 22
分子量: 
The recombinant cynomolgus FGFR4 is a disulfide-linked homodimer. The reduced monomer comprises 589 amino acids and has a calculated molecular mass of 65.6 KDa.The apparent molecular mass of the protein is approximately 97 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

FGFR4 / FGF Receptor 4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FGFR4 / FGF Receptor 4蛋白背景综述

FGFR4, also designated as CD334, is a member of the fibroblast growth factor receptor subfamily which belongs to the tyrosine protein kinase superfamily. Upon ligand binding, FGFRs undergo dimerization and autophosphorylation, intiating a cascade of downstream signal pathways, ultimately influencing a variety of physiological and pathological cellular processes including mitogenesis and differentiation. FGFR members is highly conserved in amino acid sequence and differ in their ligand affinities and tissue distribution. FGFR4, a type I transmembrane glycoprotein, contains 3 immunoglobulin-like domains in the extracellular domain and a cytoplasmic tyrosine-kinase domain. FGFR4 expression is detected in gastrointestinal epithelial cells, pancreas, as well as gastric and pancreatic cancer cell lines. FGFR4 is reported to be a high affinity receptor for both acidic and basic fibroblast growth factor, and also binds to FGF19. Like FGFR1-3, several isoforms of FGFR4 are generated by alternative splicing of the mRNAs. Although its specific function is unknown, growing studies have indicated that FGFR4 plays a role in tumorigenesis and malignace of cetain carcinomas such as breast and ovarian tumors.

参考文献

Partanen J. et al., 1991, EMBO J. 10: 1347-54.
Ron D. et al., 1993, J Biol Chem. 268: 5388-94.
Marics I. et al., 2002, Development. 129: 4559-69.
Bnage J. et al., 2002, Cancer Res. 62: 840-7.

规格：50ug

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