TNFRSF11B蛋白产品信息
别名: TNFRSF11B
表达方式:
A DNA sequence encoding the cynomolgus TNFRSF11B (F7G7U5) (Met28-Leu428) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells
TNFRSF11B Protein QC Testing
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 49
分子量:
The recombinant cynomolgus TNFRSF11B is a disulfide-linked homodimer. The reduced monomer comprises 621 amino acids and has a calculated molecular mass of 65 KDa.The apparent molecular mass of the protein is approximately 97 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
TNFRSF11B Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
TNFRSF11B蛋白背景综述
Tumor necrosis factor receptor superfamily member 11B, also known as Osteoprotegerin, Osteoclastogenesis inhibitory factor and TNFRSF11B, is a secreted protein. TNFRSF11B contains two death domains and four TNFR-Cys repeats. TNFRSF11B is highly expressed in ***** lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. It is detected at very low levels in brain, placenta and skeletal muscle. It is highly expressed in fetal kidney, liver and lung. TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. It inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. TNFRSF11B may also play a role in preventing arterial calcification. It may act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood.
参考文献
Simonet W.S. et al., 1997, Cell. 89: 309-19.
Yasuda H. et al., 1998, Endocrinology. 139: 1329-37.
Ota T. et al., 2004, Nat Genet. 36: 40-5.
Zhang Z. et al., 2004, Protein Sci. 13: 2819-24.
规格：50ug
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