Dehydropeptidase-I / DPEP1 Protein|技术资料|价格

Dehydropeptidase-I / DPEP1蛋白产品信息

别名: DPEP1, MDP, RDP
表达方式: 
A DNA sequence encoding the human DPEP1 (P16444) (Met1-Ser385) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

Dehydropeptidase-I / DPEP1 Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 17
分子量: 
The recombinant human DPEP1 consists of  380 amino acids and predicts a molecular mass of 42.5 KDa. It migrates as an approximately 44-47 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Dehydropeptidase-I / DPEP1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Dehydropeptidase-I / DPEP1蛋白背景综述

Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I may be a candidate target in PDAC for designing improved treatments. It uses zinc as a cofactor and acts as a disulfide-linked homodimer.

参考文献

Toiyama Y. et al., 2011, J Gastroenterol. 46 (2): 153-63.
Zhang G. et al., 2012, PLoS One. 7 (2): e31507.
Okamoto T. et al., 2011, Mod Pathol. 24 (2): 267-76.

规格：20ug

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