MBD2 / DPEP2 Protein|MBD2 / DPEP2蛋白质|技术资料|现货

MBD2 / DPEP2蛋白产品信息

别名: DPEP2
表达方式: 
A DNA sequence encoding the human DPEP2 (AAH24021.1) (Met1-Ser376) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

MBD2 / DPEP2 Protein QC Testing

纯度: > 90% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 33
分子量: 
The recombinant human DPEP2 consists of  355 amino acids and predicts a molecular mass of 39.4 KDa. It migrates as an approximately 47 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS , pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

MBD2 / DPEP2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MBD2 / DPEP2蛋白背景综述

MBD2, also known as DPEP2, is a nuclear protein. It belongs to a family related by the presence in each of a methyl-CpG-binding domain (MBD). Besides MBD2, the family members also include MECP2, MBD1, MBD3, and MBD4. Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1, and MBD2 can also repress transcription from methylated gene promoters. It is reported that MBD2 functions as a demethylase. MBD2 may function as a mediator of the biological consequences of the methylation signal.

参考文献

Hendrich B. et al., 1999, Mamm Genome. 10 (9): 906-12.
Brackertz. et al., 2002, J Biol Chem. 277 (43): 40958-66.
Zhang Y. et al., 1999, Nat Genet. 23 (1): 58-61.

规格：20ug

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