Rat PROCR / EPCR Protein|技术资料|厂家现货

PROCR / EPCR蛋白产品信息

别名: PROCR
表达方式: 
A DNA sequence encoding the rat PROCR (Met1-Ser213) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

PROCR / EPCR Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asn 21
分子量: 
The recombinant rat PROCR comprises 204 amino acids and predicts a molecular mass of 23.2 kDa. The apparent molecular mass of  the recombinant protein is approximately 33-37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PROCR / EPCR Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PROCR / EPCR蛋白背景综述

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells(cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occur when it does not. When still bound to EPCR, activated protein C performs its cytoprotective effects.

参考文献

Nicolaes GA. et al., 2003, Semin Vasc Med. 3 (1): 33-46.
Esmon CT. 2003, Chest. 124 (3): 26-32.
Mosnier LO. et al., 2007, Blood. 109: 3161-3172.

规格：20ug

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