Rat CD226 / DNAM-1 Protein|技术资料|现货

CD226 / DNAM-1蛋白产品信息

别名: CD226
表达方式: 
A DNA sequence encoding the rat CD226 (D3ZS97) (Met1-Ile265) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

CD226 / DNAM-1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 32
分子量: 
The recombinant rat CD226/Fc is a disulfide-linked homodimer. The reduced monomer comprises 475 amino acids and has a predicted molecular mass of 53.6 kDa. The apparent molecular mass of the protein is approximately 62-68 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD226 / DNAM-1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD226 / DNAM-1蛋白背景综述

The leukocyte adhesion molecule DNAM1, also known as CD226, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. DNAM1 is identified as an intercellular adhesion molecule which are constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes/macrophages, and a subset of B lymphocytes. The poliovirus receptor (PVR or CD155) and its family member nectin 2 (CD112) have been identified as the ligands for DNAM1. Interaction of DNAM1 with the ligands induces NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. DNAM1 also plays an important role in immune surveillance of tumor development and is involved in triggering naive T cell differentiation and proliferation. Similarly, murine DNAM1 and PVR homologues physically and functionally bind each other in vivo, and ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. Within the ECD, mouse DNAM1 shares 52% and 86% aa sequence identity with human and rat DNAM1, respectively.

参考文献

Shibuya A. et al., 1996, Immunity. 4 (6): 573-81.
Shibuya K. et al., 2003, J Exp Med. 198 (12): 1829-39.
Tahara HS. et al., 2005, Biochem Biophys Res Commun. 329 (3): 996-1000.
Iguchi-Manaka A. et al., 2008, J Exp Med. 205 (13): 2959-64.

规格：50ug

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