Cynomolgus OLR1 / LOX1 Protein |价格|厂家

OLR1 / LOX1蛋白产品信息

别名: OLR1
表达方式: 
A DNA sequence encoding the cynomolgus OLR1 (G7PJT2) (Ser61-Gln273) was expressed with a polyhistide tag at the N-terminus.
种属: Cynomolgus
表达宿主: Human Cells

OLR1 / LOX1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant heterodimer of cynomolgus OLR1 comprises 233 amino acids and has a calculated molecular mass of 26.9 KDa. The apparent molecular mass of the protein is approximately 37 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

OLR1 / LOX1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

OLR1 / LOX1蛋白背景综述

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a receptor protein which belongs to the C-type lectin superfamily. Lectin-like oxidized LDL receptor-1 (LOX-1) was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX-1 is inducted by inflammatory stimuli, so LOX-1 is thought to be involved in the development of atherosclerotic lesions. It is an important cell surface receptor for the progression of atherosclerosis. LOX-1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. LOX-1 expression is also induced in smooth muscle cells in response to proinflammatory and oxidative stimuli. LOX-1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2.

参考文献

Hinagata J. et al., 2006, Cardiovasc Res. 69 (1): 263-71.
Melan MA. et al., 1994, Plant Physiol. 105 (1): 385-393.
Saito A. et al., 2010, Acta Neurochir (Wien). 152 (4): 589-95.

规格：20ug

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