Cynomolgus CD14 Protein|现货|价格|参数

CD14蛋白产品信息

别名: CD14
表达方式: 
A DNA sequence encoding the cynomolgus CD14(B3Y6B8) (Met1- Met344) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

CD14 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Thr 20
分子量: 
The recombinant cynomolgus CD14 comprises 336 amino acids and has a calculated molecular mass of 36.5 KDa. The apparent molecular mass of it is approximately  44-48 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD14 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD14蛋白背景综述

CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists as two forms, either anchored into the membrane by a GPI-anchor tail (mCD14) or present as a soluble form (sCD14) in normal serum and body fluids. CD14 was first described as a pattern recognition receptor for lipopolysaccharide (LPS) and a variety of ligands derived from different microbial sources, along with the co-receptors Toll-like receptor TLR 4 and MD-2. The binding of CD14 and LPS depends on the presence and catalytic activity of lipopolysaccharide-binding protein (LBP). Besides its endotoxin signaling function, CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Multiple transcript variants resulting from alternative splicing encode the same isoform of CD14.

参考文献

Simmons DL. et al., 1989, Blood. 73: 284-9.
Goyert SM. et al., 1988, Science. 239: 497-500.
Heidenreich S. et al., 1999, J Leukoc Biol. 65: 737-43.
Power CP. et al., 2004, J Immunol. 173: 5229-37.
Asea A. et al., 2000, Nat Med. 6: 435-42.

规格：50ug

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