Cynomolgus / Rhesus CTLA4 / CD152 Protein|现货|价格

CTLA4 / CD152蛋白产品信息

别名: CTLA4
表达方式: 
A DNA sequence encoding the cynomolgus/rhesus CTLA4 (Q9BDC4) (Met1-Asp161) was expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus CTLA4 sequences are identical.
种属: Cynomolgus
表达宿主: Human Cells

CTLA4 / CD152 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 37
分子量: 
The recombinant cynomolgus/rhesus CTLA4 is a disulfide-linked homodimer. The reduced monomer comprises 366 amino acids and has a calculated molecular mass of 40.4 KDa.The apparent molecular mass of the protein is approximately 52 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CTLA4 / CD152 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CTLA4 / CD152蛋白背景综述

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I  membrane protein and a member of the immunoglobulin superfamily. It is widely expressed with highest levels in lymphoid tissues. CTLA4 contains a extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants encoding different isoforms have been characterized. CTLA4 is similar to the T-cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus (SLE), Graves disease (GRD), Celiac disease type 3 (CELIAC3) and Hepatitis B virus infection ( HBV infection ).

参考文献

Dariavach P. et al.,1988, Eur J Immunol. 18 (12): 1901-5.
Waterhouse P. et al., 1995. Science. 270 (5238): 985-8.
Magistrelli G. et al.,1999, Eur J Immunol. 29 (11): 3596-602.
Schneider H. et al., 2006, Science. 313 (5795): 1972-5.
Rudd CE. et al., 2009, Immunol Rev. 229 (1): 12-26.

规格：100ug

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