BMPR1B / ALK6 Protein|技术资料|现货

BMPR1B / ALK6蛋白产品信息

别名: ALK6
表达方式: 
A DNA sequence encoding the human ALK6 (Lys14-Arg126) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

BMPR1B / ALK6 Protein QC Testing

纯度: (54.4+36.1) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Lys 14
分子量: 
The recombinant human ALK6/Fc is a disulfide-linked homodimer. The reduced monomer comprises 354 amino acids and has a predicted molecular mass of 39.7 kDa. The apparent molecular mass of the protein is approximately 110 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BMPR1B / ALK6 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BMPR1B / ALK6蛋白背景综述

BMPR1B(bone morphogenetic protein receptor, type IB,,His&GST-tagged), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. It contains 1 GS domain and 1 protein kinase domain. In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations. BMPR1B is the major transducer of signals in these condensations. On ligand binding, it forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR1B also is a receptor for BMP7/OP-1 and GDF5. The BMPR1B receptor plays a role in the formation of middle and proximal phalanges. Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies and brachydactyly type A2.

参考文献

Ide H. et al., 1998, Cell Genet. 81 (3-4): 285-6.
Mishina Y. et al., 2004, J Biol Chem. 279 (26): 27560-6.
Yoon BS. et al., 2005, Proc Natl Acad Sci. 102 (14): 5062-7.

规格：100ug

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