CRP / C-reactive Protein(Native)|技术资料|现货

CRP / C-reactive蛋白产品信息

别名: CRP, PTX1
表达方式: 
A DNA sequence encoding the human CRP (P02741-1) (Met1-Pro224) was expressed and purified.
种属: Human
表达宿主: Human Cells

CRP / C-reactive Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 19
分子量: 
The recombinant human CRP consists of 206 amino acids and has a predicted molecular mass of 23 kDa. As a result of glycosylation, the apparent molecular mass of CRP is approximately 26 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile 20mM Tris, 0.2M NaCl, 5mM CaCl2, pH 8.0.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CRP / C-reactive Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CRP / C-reactive蛋白背景综述

C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

参考文献

Pepys MB. et al., 2003, J Clin Invest. 111 (12): 1805-12.
Thompson D. et al., 1999, Structure. 7(2): 169-77.

规格：200ug

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