TNFSF11 / OPGL / CD254蛋白产品信息
别名:
TNFSF11, RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
表达方式:
A DNA sequence encoding the human TNFSF11 (O14788-2) (Gly 63-Asp 244) was expressed.
种属: Human
表达宿主: Human Cells
TNFSF11 / OPGL / CD254 Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly 63
分子量:
The recombinant human TNFSF11 consists of 182 amino acids and has a calculated molecular mass of 20.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 27 kDa due to the glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
TNFSF11 / OPGL / CD254 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
TNFSF11 / OPGL / CD254蛋白背景综述
TNFSF11(tumor necrosis factor (ligand) superfamily, member 11,human IgG1-Fc chimera), also known as OPGL and CD254, is a member of the tumor necrosis factor (TNF) cytokine family. TNFRSF11A and OPG, cooperating with prostaglandin, mediating osteoclastognesis and bone loss through systemic activation of T cells, regulating lymph node organogenesis lymphocyte development and interactions between T cells and dendritic cells, activating the antiapoptotic serine threonine kinase AKT/PKB through a signal complex involving TRAF6 and SRC. TNFSF11 is a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. It augments the ability of dendritic cells to stimulate naive T-cell proliferation. TNFSF11 may be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. It may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2.
参考文献
Wong BR. et al., 1997, J Biol Chem. 272 (40): 25190-4.
Anderson DM. et al., 1997, Nature. 390 (6656): 175-9.
Schramek D. et al., 2010, Nature. 468(7320): 98-102.
Gonzalez-Suarez E. et al., 2010, Nature. 468 (7320): 103-7.
规格：10ug
关 键 词：TNFSF11 / OPGL / CD254 Protein,技术资料,现货，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
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