Rat DSC2 / Desmocollin-2 Protein|技术资料|现货

DSC2 / Desmocollin-2蛋白产品信息

别名: DSC2
表达方式: 
A DNA sequence encoding the rat DSC2 (Q3T1K6)(Met1-Pro694) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

DSC2 / Desmocollin-2 Protein QC Testing

纯度: (41%+45) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Cys 29
分子量: 
The recombinant rat DSC2 comprises 677 amino acids and predicts a molecular mass of 76.1 kDa. The apparent molecular mass of  the recombinant protein is approximately 76 and 91 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

DSC2 / Desmocollin-2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DSC2 / Desmocollin-2蛋白背景综述

Desmocollin-2, also known as Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DSC2 and CDHF2, is a single-pass type I  membrane protein which contains five cadherin domains. The desmocollins are members of the desmosomal cadherin family of cell-cell adhesion molecules. They are essential constituents of desmosomes, intercellular junctions that play a critical role in the maintenance of tissue integrity in epithelia and cardiac muscle. In humans, three desmocollins (DSC1, DSC2 and DSC3) have been described. DSC2 / CDHF2 is component of intercellular desmosome junctions. It is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 / CDHF2 may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death.

参考文献

Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
Khan K. et al., 2006, Br J Cancer. 95 (10): 1367-70.
Ramachandran P. et al., 2006, J Proteome Res. 5: 1493-503.
Syrris P. et al., 2006, Am J Hum Genet. 79: 978-84.
Beffagna G. et al., 2007, BMC Med Genet. 8: 65.

规格：50ug

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