Cynomolgus CD27 / TNFRSF7 Protein|技术资料|价格

CD27 / TNFRSF7蛋白产品信息

别名: CD27
表达方式: 
A DNA sequence encoding the cynomolgus CD27 (F7BYS2) (Met1-Ile192) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

CD27 / TNFRSF7 Protein QC Testing

纯度: (87.6+8.4)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Thr 21
分子量: 
The recombinant cynomolgus CD27 is a disulfide-linked homodimer. The reduced monomer comprises 413 amino acids and has a calculated molecular mass of 46.3 KDa.The apparent molecular mass of the protein is approximately 59 and 36 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Please contact us for any concerns or special requirements.

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD27 / TNFRSF7蛋白背景综述

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, and during which, adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling processes. In addition, a proapoptotic protein named SIVA, is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.

参考文献

Borst J. et al., 2005, Curr Opin Immunol. 17: 275-81.
Kobata T. et al., 1995, Proc Natl Acad Sci. 92: 11249-53.
Jacquot S. 2000, Immunol Res. 21: 23-30.
Arens R. et al., 2004, J Immunol. 173: 3901-8.
Akiba H. et al., 1998, J Biol Chem. 273: 13353-8.
Fortin A. et al., 2004, J Biol Chem. 279: 28706-14.

规格：50ug

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