Cynomolgus / Human TNFSF12 Protein|技术资料|价格

TNFSF12蛋白产品信息

别名: TNFSF12
表达方式: 
A DNA sequence encoding the cynomolgus TNFSF12 (F7HGN4) (Ser94-His249) was expressed with the Fc region of mouse IgG1 at the N-terminus. Cynomolgus and Human TNFSF12 sequences are identical.
种属: Cynomolgus
表达宿主: Human Cells

TNFSF12 Protein QC Testing

90094-C04H
纯度: (72.2+25.9) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp
分子量: 
The recombinant cynomolgus TNFSF12 is a disulfide-linked homodimer. The reduced monomer comprises 392 amino acids and has a calculated molecular mass of 43.8 KDa. The apparent molecular mass of it is approximately 47 and 34 KDa respectively in SDS-PAGE due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TNFSF12 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TNFSF12蛋白背景综述

TNFSF12 is a member of the tumor necrosis factor (TNF) ligand family. Iit is a cytokine and also a ligand for the FN14/TWEAKR receptor. It binds to FN14 and possibly also to TNRFSF12/APO3. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. TNFSF12 is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. It also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

参考文献

Wiley SR. et al., 2004, Cytokine Growth Factor Rev. 14 (3-4): 241-9.
Campbell. S et al., 2006, Front Biosci. 9: 2273-84.
Lynch CN. et al., 1999, J Biol Chem. 274 (13): 8455-9.

规格：20ug

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