CD45 / PTPRC蛋白产品信息
别名: PTPRC
表达方式:
A DNA sequence encoding the mouse PTPRC (NP_035340.3) (Met1-Lys425) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells
CD45 / PTPRC Protein QC Testing
纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 24
分子量:
The recombinant mouse PTPRC /Fc is a disulfide-linked homodimer. The reduced monomer comprises 643 amino acids and has a predicted molecular mass of 71.7 KDa. The
apparent molecular mass of the protein is approximately 118 KDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CD45 / PTPRC Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD45 / PTPRC蛋白背景综述
B220, also known as CD45 and PTPRC, is a member of the protein tyrosine phosphatase (PTP) family. PTPs regulate a variety of cellular processes including cell growth,
differentiation, mitotic cycle, and oncogenic transformation. B220 is expressed in lymphomas, B-cell chronic lymphocytic leukemia, hairy cell leukemia, and acute
nonlymphocytic leukemia.B220 is a receptor type PTP since it contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic
domains. B220 is an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen
receptor complexes or by activating various Src family kinases required for the antigen receptor signaling. B220 also suppresses JAK kinases, and, thus, functions as a
negative regulator of cytokine receptor signaling.
参考文献
Brown VK. et al., 1994, J Biol Chem. 269 (25): 17238-44.
Koretzky GA. et al., 1993, J Biol Chem. 268 (12): 8958-64.
Ng DH. et al., 1996, J Biol Chem. 271 (3): 1295-300.
规格：50ug
关 键 词：Mouse B220 / CD45 / PTPRC Protein,现货,产品详情，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
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