Rat GHR / Growth Hormone Receptor Protein|参数|价格

GHR / Growth Hormone Receptor蛋白产品信息

别名: GHR
表达方式: 
A DNA sequence encoding the rat GHR (P16310-1) (Met1-Arg265) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

GHR / Growth Hormone Receptor Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 19
分子量: 
The recombinant rat GHR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 488 amino acids and has a predicted molecular mass of 55.4 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GHR / Growth Hormone Receptor Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GHR / Growth Hormone Receptor蛋白背景综述

Growth hormone receptor, also known as GH receptor, Somatotropin receptor and GHR, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.

参考文献

Leung DW. et al., 1987, Nature. 330:537-43.
Sobrier M-L. et al., 1997, J Clin Endocrinol Metab. 82: 435-7.
Enberg B. et al., 2000, Eur J Endocrinol. 143: 71-6.
Pantel J. et al., 2000, J Biol Chem. 275: 18664-9.
Jorge AAL. et al., 2004, Clin Endocrinol. (Oxf.) 60: 36-40.

规格：50ug

关 键 词：Rat GHR / Growth Hormone Receptor Protein,参数,价格，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家

CANSPEC品质提供的Rat GHR / Growth Hormone Receptor Protein|参数|价格性能**，其优良的品质满足您不同实验的多种需求。

本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com 或 www.4006087598.com