Rat CSF2RB Protein|技术资料|现货

CSF2RB蛋白产品信息

别名: CSF2Rb, Csf2rb1
表达方式: 
A DNA sequence encoding the rat CSF2Rb (Met1-Trp440) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

CSF2RB Protein QC Testing

纯度: (24.0+69.6 )% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His 23
分子量: 
The recombinant rat CSF2Rb/Fc is a disulfide-linked homodimer. The reduced monomer comprises 659 amino acids and has a predicted molecular mass of 75.1 kDa. The apparent molecular mass of the protein is approximately 123 and 89 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CSF2RB Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CSF2RB蛋白背景综述

Colony stimulating factor 2 receptor, beta, low-affinity, also known as Cytokine receptor common subunit beta, CSF2RB, CDw131, and CD131, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and Type 4 subfamily. It is a 897 amino acid protein which the sequence is further processed into a mature form. The cytokine receptor is a heterodimer of an alpha and a beta subunit, and this beta subunit (CD131) is also the common and high affinity receptor to the interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. It contains two fibronectin type-III domains. The WSXWS motif of CD131 appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of CD131 is required for JAK interaction and/or activation.

参考文献

Mulhern TD. et al., 2000, J Mol Biol. 297: 989-1001.
Carr PD. et al., 2001, Cell. 104: 291-300.
Carr PD. et al., 2006, Acta Crystallogr. F 62: 509-13.
Selleri S. et al., 2008, J Transl Med. 6 : 17.

规格：50ug

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