Rat CD276 / B7-H3 Protein|现货|参数

CD276 / B7-H3蛋白产品信息

别名: CD276, B7h3
表达方式: 
A DNA sequence encoding the rat CD276 (Q7TPB4)(Met1-Phe244) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

CD276 / B7-H3 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Val 29
分子量: 
The recombinant rat CD276 comprises 227 amino acids and predicts a molecular mass of 25 kDa. The apparent molecular mass of  the recombinant protein is approximately 43 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD276 / B7-H3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD276 / B7-H3蛋白背景综述

B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are known to modulate T cell receptor (TCR)-mediated T cell activation by providing co-signals that are either stimulatory or inhibitory. B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3 is a negative regulator that preferentially affects T(H)1 responses. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. Recently, B7-H3 expression has also been found in a variety of different human cancers, including prostate cancer, clear cell renal cell carcinoma (ccRCC), non-small-cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, ovarian cancer, colorectal cancer (CRC) and urothelial cell carcinoma. B7-H3 was expressed in some human cancers and correlated with poor outcome of cancer patients.

参考文献

Loos M. et al., 2010, Clin Dev Immunol. 2010: 683875.
Nagashima O. et al., 2008, J Immunol. 181 (6): 4062-71.
Suh WK. et al., 2003, Nat Immunol. 4 (9): 899-906.
Waschbisch A. et al., 2008, Arthritis Rheum. 58 (11): 3600-8.

规格：50ug

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Sun J. et al., 2010, Cancer Immunol Immunother. 59 (8): 1163-71.