Mouse IFNB1 / IFN-beta / Interferon beta Protein|技术资料|现货

IFNB1 / IFN-beta / Interferon beta蛋白产品信息

别名: IFNB1
表达方式: 
A DNA sequence encoding the mouse IFNB1 (P01575) (Met 1-Asn 182)  was fused with five amino acids (DDDDK) at the C- terminus was expressed and purified.
种属: Mouse
表达宿主: Human Cells

IFNB1 / IFN-beta / Interferon beta Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Val 19
分子量: 
The recombinant mouse IFNB1 consists of 166 amino acids and has a calculated molecular mass of 20.3 kDa. The recombinant protein migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IFNB1 / IFN-beta / Interferon beta Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IFNB1 / IFN-beta / Interferon beta蛋白背景综述

Interferon beta 1(IFN beta1) or IFNB1 is one type of IFN beta proteins that is a member of the Interferon type I family. Interferon beta 1(IFN beta1) or IFNB1 is produced in large quantities by fibroblasts and binds to a specific cell surface receptor complex known as the IFN alpha receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains as other members of IFN1 famlily do. The induction of interferon beta (IFNB1) is a key event in the antiviral immune response. It has shown that treatment with IFN beta affects NK cell cycle without altering NK cell apoptosis in MS patients. Treated with IFN beta alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of the cell cycle. There was no difference in NK cell apoptosis markers. Synthetic interferons (IFNs) are used in the treatment of several types of cancer. It has also been proved that apoptosis was decreased by IFN treatment, whereas inhibition of proliferation is caused by cell cycle arrest in late S-phase.

参考文献

Sanvito L. et al., 2011, J Neuroimmunol. 236 (1-2) : 111-7.
Erdmann J. et al., 2011, J Interferon Cytokine Res. 31 (5): 451-8.
Biron CA. et al., 2002, Curr Top Microbiol Immunol. 263: 7-27.

规格：20ug

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