Cynomolgus REG1B / PSPS2 Protein|技术资料|现货

REG1B / PSPS2蛋白产品信息

别名: REG1B
表达方式: 
A DNA sequence encoding the cynomolgus REG1B (Met1-Asn166) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

REG1B / PSPS2 Protein QC Testing

纯度: (56.5+40)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln16
分子量: 
The recombinant cynomolgus REG1B comprises 155 amino acids and has a calculated molecular mass of 17.7 KDa. The apparent molecular mass of the protein is approximately 18 and 20 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

REG1B / PSPS2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

REG1B / PSPS2蛋白背景综述

Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human REG1A. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation.

参考文献

Moriizumi SS. et al., 1994, Biochim Biophys Acta. 1217: 199-202.
De Reggi M. et al., 1995, Eur J Biochem. 230: 503-10.
Bartoli C. et al., 1993, FEBS Lett. 327: 289-93.

规格：50ug

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