CD28 / TP44 Protein|CD28 / TP44蛋白质|现货|价格

CD28 / TP44蛋白产品信息

别名: CD28
表达方式: 
A DNA sequence encoding the human CD28 (P10747-1) (Met 1-Pro 152) was expressed with six amino acids (LEVLFQ) at the C- terminus.
种属: Human
表达宿主: Human Cells

CD28 / TP44 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asn 19
分子量: 
The recombinant human CD28 consists of  141 amino acids and predicts a molecular mass of 15.9 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD28 / TP44 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD28 / TP44蛋白背景综述

T-cell-specific surface glycoprotein CD28, also known as TP44 and CD28, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD28 / TP44 is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD28 / TP44 is expressed in T-cells and plasma cells, but not in less mature B-cells. CD28 / TP44 is involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. CD28 / TP44 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. CD28 / TP44 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

参考文献

Linsley PS. et al., 1993, Annu Rev Immunol. 11 :191-212.
Edmead CE. et al., 1997, Int J Biochem Cell Biol. 29 (8-9):1053-7.
Woerly G. et al., 2002, J Leukoc Biol. 72 (4): 769-79.

规格：100ug

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