Mouse CXADR / CAR Protein|价格|参数

CXADR / CAR蛋白产品信息

别名: CXADR
表达方式: 
A DNA sequence encoding the mouse CXADR (NP_001020363.1) (Met 1-Gly 237) was expressed with six amino acids (ENLYFQ) at the C- terminus.
种属: Mouse
表达宿主: Human Cells

CXADR / CAR Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 20
分子量: 
The recombinant mouse CXADR consists of 225 amino acids and has a calculated molecular mass of 25 kDa. The recombinant protein migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXADR / CAR Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CXADR / CAR蛋白背景综述

CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a 46 kDa type I transmembrane glycoprotein expressed on the basolateral surface, and belongs to the CTX family of the Ig superfamily. It is a receptor for group B coxsackieviruses and subgroup C adenoviruses and also acts as a homophilic adhesion molecule within junctional complexes, notably between epithelial cells lining body cavities and within myocardial intercalated discs. CXADR structrually comprises two extracellular immunoglobulin domains, a transmembrane helix and a C-terminal intracellular domain. The N-terminal Ig domain (D1) of CXADR is necessary and sufficient for adenovirus binding. The C-terminus interacts with several cytoplasmic junctional proteins, microtubules and the actin cytoskeleton. Pairs of transmembrane domains of CXADR associate with each other in a detergent cloud that mimics a cellular plasma membrane. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

参考文献

Tomko RP. et al., 1997, Proc Natl Acad Sci. 94 (7): 3352-6.
van Raaij MJ. et al., 2001, Structure. 8 (11): 1147-55.
Cohen C.J. et al., 2001, J Biol Chem. 276 (27): 25392-8.
Carson SD. et al., 2002, Rev Med Virol. 11 (4): 219-26.
Selinka HC. et al., 2004, Med Microbiol Immunol. 193 (2-3): 127-31.
Philipson L. et al., 2004, Curr Top Microbiol Immunol. 273:87-111.
Raschperger E. et al., 2006, Exp Cell Res. 312: 1566-80.

规格：20ug

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