Cynomolgus ALCAM Protein|技术资料|价格

ALCAM蛋白产品信息

别名: ALCAM
表达方式: 
A DNA sequence encoding the cynomolgus ALCAM (G7NZQ8) (Met1-Ala526) was expressed with a polyhistidine tag at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

ALCAM Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Trp 28
分子量: 
The recombinant cynomolgus ALCAM comprises 510 amino acids and has a calculated molecular mass of 57.3 KDa. The apparent molecular mass of the protein is approximately 65-68 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ALCAM Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ALCAM蛋白背景综述

ALCAM (activated leukocyte cell adhesion molecule) is a type I  membrane glycoprotein and a member of the immunoglobulin superfamily. It is also known as CD166, MEMD, SC-1/DM-GRASP in the chicken, and KG-CAM in the rat. ALCAM / CD166 has five extracellular immunoglobulin-like domains which facilitates heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. While expressed in a wide variety of tissues and cells, ALCAM is restricted to subsets of cells usually involved in dynamic growth and / or migration processes. ALCAM is highly associated not only with embryonic hematopoiesis but also vasculoangiogenesis. ALCAM can bind itself homotypically and is also capable of binding CD6, NgCAM, and other unidentified brain proteins, and thus is Involved in neurite extension by neurons via heterophilic and homophilic manners. ALCAM / CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- cells and B-cells to activated leukocytes. Further, ALCAM has also been observed to be upregulated on highly metastasizing melanoma cell lines, suggesting a role in tumor migration.

参考文献

Bowen MA. et al., 1995, J Exp Med. 181:2213-20.
Aruffo A. et al., 1997, Immunol Today. 18: 498-504.
Degen W. G. et al., 1998, Am J Pathol. 152: 805-13.
Van K. L. et al., 2001, J Biol Chem. 276: 25783-9.
Hirata H. et al., 2006, Cells Tissues Organs. 184 (3-4):172-80.
Jezierska A. et al., 2006, Med Sci Monit.12 (7): BR245-256.

规格：100ug

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