ICOSLG / B7-H2 / ICOSL / CD275 Protein|现货|价格

ICOSLG / B7-H2 / ICOSL / CD275蛋白产品信息

别名: ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
表达方式: 
A DNA sequence encoding the human ICOSLG (O75144-1) (Met1-Ser258)  was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

ICOSLG / B7-H2 / ICOSL / CD275 Protein QC Testing

纯度: (96.1+2.0)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 19
分子量: 
The recombinant human ICOSLG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 481 amino acids and has a predicted molecular mass of 53.7 kDa. The apparent molecular mass of the protein is approximately 66-76 and 33 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ICOSLG / B7-H2 / ICOSL / CD275 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ICOSLG / B7-H2 / ICOSL / CD275蛋白背景综述

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein. The receptor binding site on ICOSL is constituted chiefly by aromatic / hydrophobic residues.

参考文献

Wiendl H. et al., 2003, Brain. 126 (5): 1026-35.
Chattopadhyay K J. et al., 2006, Immunol. 177 (6): 3920-9.

规格：100ug

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