VSIG4 Protein|VSIG4蛋白质|价格

VSIG4蛋白产品信息

别名: VSIG4, CRIg, Z39IG
表达方式: 
A DNA sequence encoding the human VSIG4 (O75144-1) (Met1-Pro283)  was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

VSIG4 Protein QC Testing

纯度: (97.2+1.4)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Arg 20
分子量: 
The recombinant human VSIG4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 505 amino acids and has a predicted molecular mass of 56.2 kDa. The apparent molecular mass of the protein is approximately 57 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

VSIG4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

VSIG4蛋白背景综述

VSIG4 ( V-set and immunoglobulin domain containing 4 ), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I  transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is abundantly expressed in several fetal tissues. In ***** tissues, the highest expression of VSIG4 is in lung and placenta. It is also expressed in resting macrophages.No VSIG4 expression appears to be present in T and B cells. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. It is a potent inhibitor of the alternative complement pathway convertases.

参考文献

Vogt L. et al., 2006, J Clin Invest. 116: 2817-26.
Helmy K. et al., 2006, Cell. 124: 915-27.
Wiesmann C. et al., 2006, Nature. 444: 217-20.
Zang X.?et al., 2006, J Clin Invest. 116: 2590-3.
Vogt L. et al.,2006, J Clin Invest. 116 (10): 2817-26.
Katschke KJ. et al., 2007, J Exp Med. 204: 1319-25.
He JQ. et al., 2008, Mol Immunol. 45: 4041-7.

规格：50ug

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