SIGIRR / TIR8 Protein|技术资料|厂家现货

SIGIRR / TIR8蛋白产品信息

别名: SIGIRR
表达方式: 
A DNA sequence encoding the human SIGIRR (Q6IA17-1) (Met1-His118)  was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells

SIGIRR / TIR8 Protein QC Testing

纯度: (96.8+1.6)% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: 
The recombinant human SIGIRR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 359 amino acids and has a predicted molecular mass of 39.5 kDa. The apparent molecular mass of the protein is approximately 47-54 and 33 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SIGIRR / TIR8 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SIGIRR / TIR8蛋白背景综述

SIGIRR (single immunoglobulin IL-1 receptor-related molecule) is a member of the interleukin 1 receptor (IL-1R) superfamily, and was identified in mouse and human. Although SIGIRR shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR is a negative regulator for Toll-IL-1R signaling. It plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium. SIGIRR-deficient colonic epithelial cells displayed commensal bacteria-dependent homeostatic defects, indicating that SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora. Moreover, SIGIRR-deficient mice developed stronger Th2 immune response and this discovery suggested that SIGIRR is important in the regulation of Th2, possibly through its impact on IL-33-ST2-mediated signaling.

参考文献

Thomassen E. et al., 1999, Cytokine. 11 (6): 389-99.
Xiao H. et al., 2007, Immunity. 26 (4): 461-75.
Bulek K. et al., 2009, J Immunol. 182 (5): 2601-9.

规格：100ug

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