CD44蛋白产品信息
别名: CD44, LHR, MDU2, MDU3, MIC4
表达方式:
A DNA sequence encoding the human CD44 (P16070-1) (Met1-Pro220) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells
CD44 Protein QC Testing
纯度: >90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 21
分子量:
The recombinant human CD44/Fc is a disulfide-linked homodimer. The reduced monomer comprises 441 amino acids and has a predicted molecular mass of 49.1 kDa. The apparent molecular mass of the protein is approximately 76 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CD44 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD44蛋白背景综述
CD44, short for Cluster of Differentiation 44, is an adhesion molecule of the hyaluronate receptor family. It is expressed in a large number of mammalian cell types. The adhesive function of CD44, like other molecules involved in inducible adhesion, is tightly regulated. Post-translational modifications, isoform expression, aggregation state, and protein associations all can affect the ligand binding properties of CD44, and these can vary depending on the cell type and the activation state of the cell. The principal ligand of CD44 is hyaluronan, and CD44 is involved in the metabolism of this compound. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one. CD44 acts in atherosclerotic plaque destabilization and neointimal proliferation after percutaneous vascular interventions. CD44 participates in many stages of atherosclerosis. CD44 also is a cell membrane protein often overexpressed on tumor cells and, being both a cell-cell and cell-extracellular matrix adhesion protein, is well positioned to contribute to this process.
参考文献
Krettek A. et al.,2009, Cardiovasc Hematol Disord Drug Targets. 9 (4): 293-302.
Johnson P. et al., 2000, Biochem Pharmacol. 59 (5): 455-65.
Kimura K. et al., 2010, Curr Opin Drug Discov Devel. 13 (1): 96-103.
Protasiewicz J. et al., 2005, Pol Merkur Lekarski. 19 (112): 559-62.
Jothy S. 2003, Clin Exp Metastasis. 20 (3): 195-201.
规格：50ug
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