Mouse ICAM2 / CD102 Protein|现货|参数

ICAM2 / CD102蛋白产品信息

别名: ICAM2, CD102
表达方式: 
A DNA sequence encoding the mouse ICAM2  (NP_034624.1) (Met 1-Gln 222)was expressed with six amino acids (LEVLFQ) at the C- terminus.
种属: Mouse
表达宿主: Human Cells

ICAM2 / CD102 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 20
分子量: 
The recombinant mouse ICAM2 consists of 210 amino acids and has a calculated molecular mass of 23.6 kDa. The recombinant protein migrates as an approximately 38-42 kDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

ICAM2 / CD102 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ICAM2 / CD102蛋白背景综述

Intercellular adhesion molecule 2, also known as ICAM-2 and CD102, is a single-pass type I  membrane protein which belongs to the immunoglobulin superfamily and ICAM family. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). It is a type I  transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). ICAM2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocyte with other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. ICAM2 may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.

参考文献

Staunton DE. et al., 1989, Nature. 339: 61-4.
Simmons DL. et al., 1995, Cancer Surv. 24: 141-55.
Fagerholm SC. et al., 2006, Blood. 108: 3379-86.
Issekutz AC. et al., 1999, J Leukoc. Biol. 65: 117-26.
Somersalo K. et al., 1995. J Biol Chem. 270: 8629-36.

规格：50ug

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