Rat DDR1 Kinase / MCK10 / CD167 Protein|价格|产品详情

DDR1蛋白产品信息

别名: DDR1
表达方式: 
A DNA sequence encoding the rat DDR1 (Q6MG19) (Met1-Thr413) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells

DDR1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 20
分子量: 
The recombinant rat DDR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 635 amino acids and has a predicted molecular mass of 70.9 kDa. The apparent molecular mass of the protein is approximately 71 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

DDR1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DDR1蛋白背景综述

Epithelial discoidin domain-containing receptor 1, also known as Tyrosine kinase DDR, Discoidin receptor tyrosine kinase, CD167a, and DDR1, is a single-pass type I  membrane protein. It belongs to the protein kinase superfamily and insulin receptor subfamily. DDR1 contains one F5/8 type C domain and one protein kinase domain. DDR1 is expressed at low levels in most ***** tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. DDR1 is abundantly expressed in breast carcinoma cell lines. DDR1 regulates cell adhesion and a broad range of cell behavior. DDR1 plays an important role as a collagen receptor, mediating intimal thickening after vascular injury. DDR1 and DDR2 are tyrosine kinase receptors activated by triple-helical collagens. Aberrant expression and signaling of these receptors have been implicated in several human diseases linked to accelerated matrix degradation and remodeling including tumor invasion, atherosclerosis and liver fibrosis.

参考文献

Hou G. et al., 2001, J Clin Invest. 107 (6): 727-35.
Abdulhussein R. et al., 2004, J Biol Chem. 279 (30): 31462-70.
Mihai C. et al., 2009, J Mol Biol. 385 (2): 432-45.
Wang CZ. et al., 2009, Am J Physiol Cell Physiol. 297 (2): C419-29.
Flynn LA. et al., 2010, J Mol Biol. 395 (3): 533-43.

规格：50ug

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