JAM3 / JAM-C Protein|技术资料|参数

JAM3 / JAM-C蛋白产品信息

别名: JAM3
表达方式: 
A DNA sequence encoding the human JAM3 (Q9BX67) (Met 1- Asn 241) was expressed with six amino acids (LEVLFQ) at the C- terminus was expressed and purified.
种属: Human
表达宿主: Human Cells

JAM3 / JAM-C Protein QC Testing

纯度: > 95% as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Val 32
分子量: 
The recombinant human JAM3 consists of  217 amino acids and predicts a molecular mass of 24.7 KDa. It migrates as an approximately 33 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

JAM3 / JAM-C Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

JAM3 / JAM-C蛋白背景综述

Junctional adhesion molecule C, also known as Junctional adhesion molecule 3, JAM3, is a single-pass type I  membrane protein which belongs to the immunoglobulin superfamily. JAM3 is widely expressed. The highest expression of JAM3 is in placenta, brain and kidney. JAM3 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. At the protein level JAM3 displays 36 and 32% identity to JAM2 and JAM1, respectively. JAM3 participates in cell-cell adhesion distinct from tight junctions. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. JAM3 is localized in the tight junctions between high endothelial cells. Unlike other proteins in the same family, this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions.

参考文献

Suzuki Y. et al.,1997, Gene. 200 (1-2): 149-56.
Arrate MP. et al., 2001, J Biol Chem. 276 (49): 45826-32.
Cunningham SA. et al., 2002, J Biol Chem. 277 (31): 27589-92.
Muller WA. et al., 2003, Trends Immunol. 24 (6): 327-34.

规格：50ug

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