TSPAN8 / Tetraspanin 8 / TM4SF3 Protein|技术资料|现货

TSPAN8 / Tetraspanin 8 / TM4SF3蛋白产品信息

别名: TSPAN8, TM4SF3
表达方式: 
A DNA sequence encoding the human TSPAN8 (P19075) (Lys110-Asn205) was expressed with an N-terminal polyhistidine tag.
种属: Human
表达宿主: Human Cells

TSPAN8 / Tetraspanin 8 / TM4SF3 Protein QC Testing

纯度: (87.8+10.7) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant human TSPAN8 comprises 116 amino acids and has a predicted molecular mass of 13.4 kDa. The apparent molecular mass of the protein is approximately 17 and 13 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TSPAN8 / Tetraspanin 8 / TM4SF3 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TSPAN8 / Tetraspanin 8 / TM4SF3蛋白背景综述

TSPAN8, also known as tetraspanin 8 and TM4SF3, is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN8 gene is expressed in different carcinomas. TSPAN8 is a cell surface glycoprotein that is known to complex with integrins. TSPAN8 is also known to efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins. TSPAN8 contributed to a selective recruitment of proteins and mRNA into exosomes, including CD106 and CD49d.

参考文献

Szala S. et al., 1990, Proc Natl Acad Sci. 87 (17): 6833-7.
Berditchevski F. et al., 2002, J Cell Sci. 114 (23): 4143-51.
Maruyama K. et al., 1994, Gene. 138 (1-2): 171-4.
Nazarenko I. et al., 2010, Cancer Res. 70 (4): 1668-78.

规格：10ug

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