Mouse SDC4 / Syndecan-4 Protein|使用说明|价格

SDC4 / Syndecan-4蛋白产品信息

别名: SDC4
表达方式: 
A DNA sequence encoding the mouse SDC4 (O35988)(Met1-Val146) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells

SDC4 / Syndecan-4 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 24
分子量: 
The recombinant mouse SDC4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 364 amino acids and has a predicted molecular mass of 40.5 kDa. The apparent molecular mass of the protein is approximately 33 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

SDC4 / Syndecan-4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SDC4 / Syndecan-4蛋白背景综述

Syndecan-4 (SDC4, Syn4), is a ubiquitous transmembrane proteoglycan that localizes to the focal adhesions of adherent cells and binds to a range of extracellular ligands, including growth factors and extracellular-matrix proteins. Through its extracellular domain, syndecan-4 cooperates with adhesion molecules and binds matrix components relevant for cell migration. As a heparan sulfate proteoglycan, SDC4 works as a coreceptor for various growth factors. Syn4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, Syn4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

参考文献

Bass MD. et al., 2002, Biochem J. 368 (1): 1-15.
Ikesue M. et al., 2011, Arterioscler Thromb Vasc Biol. 31 (5): 1066-74.
Rodríguez-Manzaneque JC. et al., 2009, Int J Biochem Cell Biol. 41 (4): 800-10.

规格：50ug

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