Jumping Translocation Breakpoint / JTB Protein|技术资料|现货

Jumping Translocation Breakpoint / JTB蛋白产品信息

别名: JTB
表达方式: 
A DNA sequence encoding the human JTB (O76095-1) (Met1-Leu105) was  fused with Fc region of mouse IgG at the C-terminus.
种属: Human
表达宿主: Human Cells

Jumping Translocation Breakpoint / JTB Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 31
分子量: 
The recombinant human JTB/mFc is a disulfide-linked homodimer. The reduced monomer comprises 309 amino acids and has a predicted molecular mass of 34.7 kDa. The apparent molecular mass of the protein is approximately 38 in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Jumping Translocation Breakpoint / JTB Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Jumping Translocation Breakpoint / JTB蛋白背景综述

Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.

参考文献

Hatakeyama S. et al., 1999, Oncogene. 18 (12): 2085-90.
Platica O. et al., 2000, Int J Oncol. 16 (5): 1055-61.
Erhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.

规格l:20ug

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