TPM4 / Tropomyosin 4 Protein|技术资料|产品详情

TPM4 / Tropomyosin 4蛋白产品信息

别名: TPM4
表达方式: 
A DNA sequence encoding the human TPM4 (P67936) (Ala2-Ile248) was expressed with an N-terminal polyhistidine tag.
种属: Human
表达宿主: Human Cells

TPM4 / Tropomyosin 4 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant human TPM4 comprises 267 amino acids and has a predicted molecular mass of 30.8 kDa. The apparent molecular mass of the protein is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TPM4 / Tropomyosin 4 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TPM4 / Tropomyosin 4蛋白背景综述

TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells it is implicated in stabilizing cytoskeleton actin filaments.

参考文献

Udeshi ND. et al., 2012, Mol Cell Proteomics. 11 (5): 148-59.
Rostila A. et al., 2012, Lung Cancer. 77 (2): 450-9.
Vlahovich N. et al., 2008, Cell Motil Cytoskeleton. 65 (1): 73-85.

规格：20ug

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