CREB3L1 / OASIS (aa 396-519) Protein|使用说明|价格

CREB3L1 / OASIS蛋白产品信息

别名: CREB3L1, OASIS
表达方式: 
A DNA sequence encoding the human CREB3L1 (Q96BA8-1) (Glu396- Ser519) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

CREB3L1 / OASIS Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 396
分子量: 
The recombinant human CREB3L1 consists of  135 amino acids and predicts a molecular mass of 15.2 KDa. It migrates as an approximately 21-31 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CREB3L1 / OASIS Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CREB3L1 / OASIS蛋白背景综述

CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells. In vitro, CREB3L1 binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. It may play a role in gliosis.

参考文献

Denard B. et al., 2011, Cell Host Microbe. 10 (1): 65-74.
Debelenko LV. et al., 2011, 50 (12): 1054-62.
Vellanki. et al., 2010, Endocrinology. 151 (9): 4146.

规格：50ug

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