APLP1 / Amyloid-like protein 1 Protein|技术资料|报价

APLP1 / Amyloid-like protein 1蛋白产品信息

别名: APLP1
表达方式: 
A DNA sequence encoding the human APLP1 (P51693-1) (Met1-Glu580) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

APLP1 / Amyloid-like protein 1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 39
分子量: 
The recombinant human APLP1 consists of  553 amino acids and predicts a molecular mass of 61.9 KDa. It migrates as an approximately 67-77 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

APLP1 / Amyloid-like protein 1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

APLP1 / Amyloid-like protein 1蛋白背景综述

APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose and insulin homeostasis. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP). APP is a type I membrane protein that is genetically linked to Alzheimer's disease.

参考文献

Wasco W. et al., 1993, Genomics. 15 (1): 237-9.
Needham BE. et al., 2008, J Pathol. 215 (2): 155-63.
Bayer TA. et al., 2000, Mol Psychiatry. 4 (6): 524-8.
Lee S. et al., 2011, Biochemistry. 50 (24): 5453-64.

规格：50ug

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