MZB1 / PERP1 Protein|MZB1 / PERP1 蛋白质|技术资料|现货

MZB1 / PERP1蛋白产品信息

别名: MGC29506, MZB1,MEDA7, PACAP
表达方式: 
A DNA sequence encoding the human MGC29506 (Q8WU39-1) (Met 1- Thr 185) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

MZB1 / PERP1 Protein QC Testing

纯度: (61+35.7) % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 23
分子量: 
The recombinant human MGC29506 consists of  174 amino acids and predicts a molecular mass of  19.4 KDa. It migrates as an approximately 22 and 20 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

MZB1 / PERP1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MZB1 / PERP1蛋白背景综述

PERP1, also known as MZB1, is an endoplasmic reticulum-localized and B cell-specific protein that is most abundantly expressed in marginal zone (MZ) B and B1 cells. PERP1 helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation. PERP1 also associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. It may exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in the hepatocarcinogenesis, and is a useful prognosticator in HCC.

参考文献

Vinayagam A. et al., 2011, Sci Signal. 4 (189): rs8.
Matsumura S. et al., 2012, Clin Cancer Res. 18 (13): 3541-51.
Flach H. et al., 2010, Immunity. 33 (5): 723-35.

规格：50ug

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