CD23 / FCER2 / FCER2A蛋白产品信息
别名: FCER2, Fcer2a
表达方式:
A DNA sequence encoding the rat FCER2 (Q6AZ45) (Glu50-Pro331) was expressed with Fc region of human IgG1 at the N-terminus.
种属: Rat
表达宿主: Human Cells
CD23 / FCER2 / FCER2A Protein QC Testing
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量:
The recombinant rat FCER2 comprises 542 amino acids and predicts a molecular mass of 60.2 kDa. The apparent molecular mass of the recombinant protein is approximately 61 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CD23 / FCER2 / FCER2A Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CD23 / FCER2 / FCER2A蛋白背景综述
Low affinity immunoglobulin epsilon Fc receptor, also known as BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23 and FCER2, is a secreted and single-pass type II membrane protein which is also exists as a soluble excreted form. There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. Unlike many of the antibody receptors, CD23 / FCER2 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells, and platelets. In flow cytometry, CD23 / FCER2 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell leukemia (CD23-negative). CD23 / FCER2 can also be demonstrated in germinal centre B-cells using immunohistochemistry, but it is not present in the resting cells of the surrounding mantle zone. CD23 / FCER2 has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
参考文献
Kikutani H. et al., 1986, Cell. 47: 657-65.
Rose K. et al., 1992, Biochem J. 286: 819-24.
Padlan EA. et al., 1993, Receptor. 3: 325-41.
Bajorath J. et al., 1996, Protein Sci. 5: 240-247.
Barna G. et al., 2008, Hematol Oncol. 26 (3): 167-70.
规格：50ug
关 键 词：Rat CD23 / FCER2 / FCER2A Protein,厂家现货,报价，实验室耗材，生化试剂，上海创赛，博飞美科，实验仪器，厂家
CANSPEC品质提供的Rat CD23 / FCER2 / FCER2A Protein|厂家现货|报价性能**，其优良的品质满足您不同实验的多种需求。
本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com 或 www.4006087598.com
