Cynomolgus BAFF / TNFSF13B Protein|技术资料|现货

BAFF / TNFSF13B蛋白产品信息

别名: TNFSF13B
表达方式: 
A DNA sequence encoding the cynomolgus TNFSF13B (F7H548) (Ala134-Leu285) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells

BAFF / TNFSF13B Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: 
The recombinant cynomolgus TNFSF13B is a disulfide-linked homodimer. The reduced monomer comprises 412 amino acids and has a calculated molecular mass of 45.5 KDa.The apparent molecular mass of the protein is approximately 47 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

BAFF / TNFSF13B Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BAFF / TNFSF13B蛋白背景综述

Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), also known as B cell-activating factor, CD257 and BAFF, is single-pass type I I membrane protein. It belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression of BAFF is found in placenta, heart, lung, fetal liver, thymus, and pancreas. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors are expressed mainly on mature B lymphocytes, and TACI binds with lowest affinity. TACI binds a protein similar to BAFFcalled A Proliferation Inducing Ligand (APRIL) with high. BCMA displays an intermediate binding phenotype and performs functions with either BAFF or APRIL to varying degrees. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells.

参考文献

Shu HB. et al., 1999, J Leukoc Biol. 65 (5): 680-3.
Schneider P. et al., 1999, J Exp Med. 189 (11): 1747-56.
Wu Y. et al., 2000, J Biol Chem. 275 (45): 35478-85.
Oren DA. et al., 2002, Nat Struct Biol. 9: 288-92.
Daridon C. et al., 2008, Autoimmun Rev. 7 (4): 267-71.

规格：20ug

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