Interferon alpha-B / IFNA8 Protein|技术资料|现货

Interferon alpha-B / IFNA8蛋白产品信息

别名: IFNA8
表达方式: 
A DNA sequence encoding the human IFNA8 (NP_002161.2)(Cys24-Glu189) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
种属: Human
表达宿主: Human Cells

Interferon alpha-B / IFNA8 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly
分子量: 
The secreted recombinant human IFNA8 consists of 168 amino acids and predicts a molecular mass of 19.6 KDa. The apparent molecular mass of the protein is approximately 26 KDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Interferon alpha-B / IFNA8 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Interferon alpha-B / IFNA8蛋白背景综述

Interferon alpha-B, also known as IFNA8, belongs to the alpha/beta interferon family. Interferons are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumorcells. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They also allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. Interferons also activate immune cells, such as natural killer cells and macrophages. They increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes. They also increase the ability of uninfected host cells to resist new infection by virus. Certain symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Produced by macrophages, IFN-alpha have antiviral activities.

参考文献

Henco K. et al., 1985, J Mol Biol. 185 (2): 227-60.
Goeddel DV. et al., 1981, Nature. 290 (5801): 20-6.
Yelverton E. et al., 1981, Nucleic Acids Res. 9 (3): 731-41.
Kempaiah P. et al., 2012, Hum Genet. 131 (8): 1375-91.

规格：50ug

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