PRKAR1A / PKR1 / PRKAR1 Protein |技术资料|厂家|价格

PRKAR1A / PKR1 / PRKAR1蛋白产品信息

别名: PRKAR1A, PKR1, PRKAR1, TSE1
表达方式: 
A DNA sequence encoding the human PRKAR1A (P10644) (Met1-Val381) was expressed with a polyhistidine tag at the C-terminus.
种属: Human
表达宿主: Human Cells

PRKAR1A / PKR1 / PRKAR1 Protein QC Testing

纯度: > 85 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: 
The recombinant human PRKAR1A consists of  391 amino acids and predicts a molecular mass of 44.3 KDa. It migrates as an approximately 47 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile 20mM Tris, 500mM Nacl, 10% glycerol, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

PRKAR1A / PKR1 / PRKAR1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

PRKAR1A / PKR1 / PRKAR1蛋白背景综述

PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating PKA, which transduces the signal throughphosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. PRKAR1A was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids Three alternatively spliced transcript variants encoding the same protein have been observed.

参考文献

Huang L J. et al., 1997, Proc Natl Acad Sci. 94 (21): 11184-9.
Herberg F W. et al., 2000, J Mol Biol. 298 (2): 329-39.
Scambler P. et al., 1987, Am J Hum Genet. 41 (5): 925-32.

规格：20ug

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