Mouse GM-CSF / CSF2 Protein|使用说明|参数

GM-CSF / CSF2蛋白产品信息

别名: CSF2 , Csfgm
表达方式: 
A DNA sequence encoding the mouse CSF2 (P01587) (Ala18-Lys141) was expressed with a polyhistidine tag at the N-terminus.
种属: Mouse
表达宿主: Human Cells

GM-CSF / CSF2 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: 
The recombinant mouse CSF2 consists of  144 amino acids and predicts a molecular mass of 16.5 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GM-CSF / CSF2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GM-CSF / CSF2蛋白背景综述

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells. GM-CSF is secreted by a variety of cell types including macrophages, T cells, mast cells, endothelial cells and fibroblasts. This cytokine has a central role in governing the proliferation, maturation, differentiation and function of granulocyte and macrophage lineage populations, as well as the migration of endothelial cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target.

参考文献

Frolova EI. et al., 1991, Proc Natl Acad Sci. 88: 4821-4.
Hamilton JA. et al., 2002, Trends Immunol. 23: 403-8.
Ebner K. et al., 2003, Blood. 102: 192-9.
Kato T. et al., 2008, J Interferon Cytokine Res. 28: 235-43.
Volmar CH. et al., 2008, Cytokine. 42: 336-44.

规格：20ug

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