Rat CD150 / SLAM / SLAMF1 Protein|厂家现货|技术资料

CD150 / SLAM / SLAMF1蛋白产品信息

别名: SLAMF1
表达方式: 
A DNA sequence encoding the rat SLAMF1 (D3ZAD7) (Met1-Leu242) was expressed with a polyhistidine tag at the C-terminus.
种属: Rat
表达宿主: Human Cells

CD150 / SLAM / SLAMF1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Thr 25
分子量: 
The recombinant rat SLAMF1 comprises 229 amino acids and predicts a molecular mass of 26 kDa. The apparent molecular mass of  the recombinant protein is approximately 44-47 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CD150 / SLAM / SLAMF1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD150 / SLAM / SLAMF1蛋白背景综述

CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I  transmembrane glycoproteins. It has a 77-residue cytoplasmic tail containing several tyrosines within motifs for Src-homology 2 (SH2)-domain binding sites, and interacts with SH2 domain protein 1A (SH2D1A) and with PTPN11. LAM is constitutively expressed on peripheral-blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of interferon γ (IFN-γ) in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.

参考文献

Svitlana V. et al., 1999, The Journal of Immunology. 162: 5719-27.
Duncan Howie. et al., 2002, Blood. 99 (3): 957-65.
Benjamin G. et al., 1995, Nature. 376: 260-3.
Hironobu Tatsuo. et al., 2000, Nature. 406: 893-7.
Svetlana P. et al., 2003,Nature Immunology. 4: 19-24.
Grant Welstead. et al., 2004, Journal of Virology. 78 (18): 9666-74.

规格：50ug

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