SIRPG / SIRP gamma蛋白产品信息
别名: SIRPG
表达方式:
A DNA sequence encoding the cynomolgus SIRPG (G7PGS5) (Met1-His360) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Cynomolgus
表达宿主: Human Cells
SIRPG / SIRP gamma Protein QC Testing
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 29
分子量:
The recombinant cynomolgus SIRPG is a disulfide-linked homodimer. The reduced monomer comprises 573 amino acids and has a calculated molecular mass of 63.6 KDa.The apparent molecular mass of the protein is approximately 69-79 KDa respectively in SDS-PAGE.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
SIRPG / SIRP gamma Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SIRPG / SIRP gamma蛋白背景综述
Signal-regulatory protein gamma, also known as SIRP-gamma, CD172 antigen-like family member B, Signal-regulatory protein beta-2, SIRP-beta-2, CD172g and SIRPG, is a single-pass type I membrane protein. SIRPG / CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. It is expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. SIRPG / CD172g contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. It is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG / CD172g is primarily expressed in the medulla on mature T lymphocytes that have undergone thymic selection. SIRPG / CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, it mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
参考文献
Ichigotani Y. et al., 2000, J Hum Genet. 45: 378-82.
Van den Berg TK. et al., 2005, J Immunol. 175 (12): 7788-9.
Piccio L. et al., 2005, Blood. 105: 2421-7.
Hatherley D. et al., 2008, Mol Cell. 31: 266-77.
规格：50ug
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