Mouse REG3B / Pap1 Protein|报价|技术资料

REG3B / Pap1蛋白产品信息

别名: REG3B, Pap, Pap1
表达方式: 
A DNA sequence encoding the mouse REG3B (NP_035166.1) (Met1-Gly175) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

REG3B / Pap1 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 27
分子量: 
The recombinant mouse REG3B comprises 160 amino acids and has a predicted molecular mass of 18.1 kDa. The apparent molecular mass of the protein is approximately 19 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

REG3B / Pap1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

REG3B / Pap1蛋白背景综述

Reg3b, also known as Pap1, is a secreted 17 kDa member of the Reg gene family, C-type lectin gene superfamily. Reg3b is constitutively expressed in the small intestine, moderately in colon and at an extremely low level in healthy pancreas. Members of the Reg family are involved in a range of physiological processes including acting as acute phase reactants, lectins, survival/growth factors for insulin-producing pancreatic beta-cells, neural cells, and epithelial cells of the digestive system. As a transcription factor, Pap1, together with the MAP kinase Sty1, are key regulators of hydrogen peroxide-induced responses in Schizosaccharomyces pombe. Pap1 can be activated quickly at low, but not high, hydrogen peroxide concentrations. Reg3b also might be a stress protein involved in the control of bacterial proliferation. Reg3b plays a protective role against intestinal translocation of the gram-negative bacterium S. enteritidis in mice but not against the gram-positive bacterium L. monocytogenes.

参考文献

Van Ampting MT. et al., 2012, Infect Immun. 80 (3): 1115-20.
Vivancos AP. et al., 2004, Mol Microbiol. 52 (5): 1427-35.
Tao J. et al., 2012, Proc Natl Acad Sci. 109 (29): E2001-9.

规格：20ug

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