RANKL / OPGL / TNFSF11 / CD254 Protein|技术资料|现货

RANKL / OPGL / TNFSF11 / CD254蛋白产品信息

别名: TNFSF11, OPGL, RANKL, TRANCE
表达方式: 
A DNA sequence encoding the human TNFSF11 (AAC51762.1) (Gly63-Asp244) was expressed with the Fc region of mouse IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

RANKL / OPGL / TNFSF11 / CD254 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp
分子量: 
The recombinant human TNFSF11/mFc  comprises 418 amino acids and has a predicted molecular mass of 47.1 kDa. The apparent molecular mass of the monomer is approximately 48-56 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

RANKL / OPGL / TNFSF11 / CD254 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

RANKL / OPGL / TNFSF11 / CD254蛋白背景综述

TNFSF11(tumor necrosis factor (ligand) superfamily, member 11,human IgG1-Fc chimera), also known as OPGL and CD254, is a member of the tumor necrosis factor (TNF) cytokine family. TNFRSF11A and OPG, cooperating with prostaglandin, mediating osteoclastognesis and bone loss through systemic activation of T cells, regulating lymph node organogenesis lymphocyte development and interactions between T cells and dendritic cells, activating the antiapoptotic serine threonine kinase AKT/PKB through a signal complex involving TRAF6 and SRC. TNFSF11 is a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. It augments the ability of dendritic cells to stimulate naive T-cell proliferation. TNFSF11 may be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. It may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2.

参考文献

Wong BR. et al., 1997, J Biol Chem. 272 (40): 25190-4.
Anderson DM. et al., 1997, Nature. 390 (6656): 175-9.
Schramek D. et al., 2010, Nature. 468 (7320): 98-102.
Gonzalez-Suarez E. et al., 2010, Nature. 468 (7320): 103-7.

规格：10ug

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