Mouse Contactin 1 / CNTN1 Protein|使用说明|价格

Contactin 1 / CNTN1蛋白产品信息

别名: CNTN1
表达方式: 
A DNA sequence encoding the mouse CNTN1 (NP_031753.1) (Met1-Leu1000) was expressed with a C-terminal polyhistidine tag.
种属: Mouse
表达宿主: Human Cells

Contactin 1 / CNTN1 Protein QC Testing

纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 21
分子量: 
The recombinant mouse CNTN1 comprises 991 amino acids and has a predicted molecular mass of 110.5 kDa. The apparent molecular mass of the protein is approximately 110-120 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Contactin 1 / CNTN1 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Contactin 1 / CNTN1蛋白背景综述

Contactin-1 (CNTN1) is a member of the contactin sbufamily belonging to immunoglobulin superfamily. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein consisting of 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains, and is expressed in numerous neuronal tissues, as well as neuroblastoma and retinoblastoma cell lines. As a cell adhesion molecule, CNTN1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that CNTN1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1, and thus is involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that CNTN1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells.

参考文献

Peles E. et al., 1995, Cell. 82: 251-60.
Pierre Kk. et al., 2001, Eur J Neurosci. 14: 645-56.
Su JL. et al., 2006, Cancer Res. 66: 2553-61.

规格：100ug

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