Mouse TIM3 / HAVCR2 Protein|厂家价格|报价

TIM3 / HAVCR2蛋白产品信息

别名: HAVCR2, Tim3, Timd3
表达方式: 
A DNA sequence encoding the mouse HAVCR2 (AAL65156.1) (Met1-Arg191) was expressed with the Fc region of human IgG1 at the C-terminus.
种属: Mouse
表达宿主: Human Cells

TIM3 / HAVCR2 Protein QC Testing

纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 22
分子量: 
The recombinant mouse HAVCR2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 411 amino acids and has a predicted molecular mass of 45.9 kDa. The apparent molecular mass of the protein is approximately 58-66 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

TIM3 / HAVCR2 Protein Usage Guide

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TIM3 / HAVCR2蛋白背景综述

Hepatitis A virus cellular receptor 2 ( HAVCR2 ), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. TIM-3 thus serves as the surface molecule that distinguishes between the two effector populations derived from naive CD4(+) T-helper cells. TIM-3 is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. Th1 cells produce cytokines ( IFN-gamma, interleukin-2, TNF-alpha and lymphotoxin ) that are commonly associated with cell-mediated immune responses against intracellular pathogens, delayed-type hypersensitivity reactions, and induction of organ-specific autoimmune diseases. It has been identified that galectin-9 is the Tim-3 ligand, and the TIM-3-galectin-9 pathway may serve to inhibit Th1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance. Dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

参考文献

Monney L. et al., 2002, Nature. 415: 536-41.
Sabatos CA. et al., 2003, Nat Immunol. 4: 1102-10.
Zhu C. et al., 2005, Nat Immunol. 6: 1245-52.
Koguchi K. et al., 2006, J Exp Med. 203: 1413-8.
Anderson AC. et al., 2006, Curr Opin Immunol. 18: 665-9.

规格：50ug

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